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Vaccine against newcastle disease, live, dry Strain La Sota.

The vaccine is a homogenous dry porous substance, of pale yellow or pale brown color, that easily dissolves in water or physiological solution without forming of flakes and dreg.

The vaccine is available in 1 −5 cm 3 vials, hermetically sealed.

Each vial contains 100–5000 doses.

One commercial dose of the vaccine corresponds to one nasal dose, being 6,7 lg EID 50/cm3 of ND virus, strain La Sota. The immunity of vaccinated chickens is forming during 2–3 weeks and keeps up to 3 months. The vaccine with biological activity no less than 8,5 lg EID 50/cm3 is applicable for use. The vaccine is harmless, areactogenic, does not possess therapeutic properties.

Clinically healthy birds of all ages are vaccinated orally, intranasally, intraocularly by coarse spray or by aerosol. Time of vaccination is determined based on antibody level estimated by haemaggltination inhibition test examining 25 blood serum samples collected from the birds in each poultry house by a general method.

Chickens should first undergo serological testing at the age of 5 to 10 days. Birds should be vaccinated if hemagglutinin titers are lower than 1:8 in 20% or more of the

samples. If hemagglutinin titers are higher than 1:8 in 80% or more of the samples, the birds should be tested every 3–5 days. If the intensity of immunity is lower than 80% (i.е. if hemagglutinin titers are lower than 1:8 in 20% or more of the samples), the birds should be revaccinated.

Further serological testing should be carried out at intervals from 14 to 28 days.

Revaccination is carried out if antibody levels in blood serum obtained from vaccinated birds and determined by hemagglutination inhibition test are less than 4 log 2 (1:16) in 20% of the samples.

The shelf life of the vaccine is 12 months from the manufacturing date if kept and transported in a dark dry place at a temperature between +2 and +10°С.